A PROCESS FOR THE PREPARATION OF PEPTIDASE SUBSTRATE ANALOGS IN WHICH THE NITROGEN ATOM OF THE CITED AMIDA LIGACATION OF A PARTIAL SUBSTRATE RETROPEPTIDE ANALYSIS WAS REPLACED BY A RADICAL DIFLUORO-METHYLENE

摘要

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent proteolytic enzymes, the inhibition of which will have useful physiological consequences in a variety of disease states.