PROCESS FOR THE PREPARATION OF XANTENE OR FLUORENE DERIVATIVES, UTEIS AS LEUCOTRIENE ANTAGONISTS

摘要

This invention provides tricyclic derivatives which are leukotriene B4 antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions characterized by an excessive release of leukotrienes. The derivatives are of the formula: CHEM or a pharmaceutically acceptable base addition salt thereof, wherein Y is -CO-, -C(=NOH)-, -CHOH-, -CH2-, or -C(=CH2)-; A is a bond or -O-; one of R1 and R2 is hydrogen and the other of R1 and R2 is -CH2CH2COOH; p is 1-16; and Z is -H or -G-Q where G is a bond, -O-, -S(O)t-, -NH-, -CH=CH-, or -C IDENTICAL C-, Q is phenyl or phenyl substituted with one or two substituents selected from the group consisting of halo, C1-C3 alkyl, C1-C3 alkoxy, acetyl, nitro, amino, trifluoromethyl, hydroxy, and -S(O)t-(C1-C3 alkyl), and each t is independently 0-2. leu