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PROCESS FOR THE PREPARATION OF 1R-CIS, 1'R-CIS, ATRACURI, SALTS WITH NEUROMUSCULAR BLOCKING EFFECTS
PROCESS FOR THE PREPARATION OF 1R-CIS, 1'R-CIS, ATRACURI, SALTS WITH NEUROMUSCULAR BLOCKING EFFECTS
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机译:具有神经肌肉阻滞作用的1R-CIS,1'R-CIS,ATRACURI,盐的制备方法
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摘要
1R-$i(cis),1'R-$i(cis) isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) salt, substantially free from other geometrical and optical isomers thereof. The 1R-$i(cis),1'R-$i(cis) isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockage, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockade), in comparison with the known mixture of geometrical and optical isomers.
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