PROCESS FOR THE PRODUCTION OF 17.alpha.-ETHINYL-17.beta.-HYDROXY-18-METHYL-4,15-ESTRADIEN-3-ONE AND NEW INTERMEDIATE PRODUCTS FOR THIS PROCESS

摘要

ABSTRACT OF THE DISCLOSUREA process for the production of 17?-ethinyl-17?-hydroxy-18-methyl-4,15-estradien-3-one is describedcomprising reacting a 17-enolester of formula II II.whereinR1 represents an alkyl radical with 1-3 carbon atoms andR2 represents an acyl or a trialkylsilyl group with 1-10carbon atomsunder palladium catalysis, with compounds of formula III III,whereinR1 represents an alkyl radical with 1-3 carbons atoms,reducing the 17-keto group to the 17-hydroxy group in amanner known in the art, reducing the aromatic A-ringaccording to Birch, with liquid ammonia, to 3-methoxy-2,5(10),15-estratrien-17.beta.;-ol, reoxidizing the 17-hydroxygroup to the 17-keto group, ethinylating the 17-ketogroup and splitting off the 3-enolether to form 17?-ethinyl-17.beta.-hydroxy-18-methyl-4,15-estradiene-3-one.