1,4-DIHYDROPYRIDINE DERIVATIVES HAVING A NITROGEN CONTAINING HETEROARYL GROUP LINKED TO THE TWO POSITION POSSESSING ANTIHYPERTENSIVE AND ANTITHROMBOTIC ACTIVITY

摘要

H-354/367 Can.- 1 -ABSTRACTThe invention concerns the preparation of compounds offormula (I)or salts thereof; whereinAr is an optionally substituted aryl radical;R represents H or an optionally substituted alkyl oraralkyl group;R1 and R2 are the same or different and are selected from Hand saturated or unsaturated, cyclic or acyclic aliphatichydrocarbon residues optionally substituted by one or moregroups selected from defined substituents.A represents a group of formula -XR3 whereinX is a group of formula -(CHR6)p-Y-(CHR7)q- or-(CHR6)r-O-(CHR7)?in which formulae: Y represents -S-, NR8 or a direct bond,p and q each represent 0,1 or 2 providing that p and q donot both represent zero when Y is a direct bond; one ofr and s represents 0, 1 or 2 and the other is zero; R6,R7 and R8 independently represent hydrogen or lower alkyl,and R3 is an optionally substituted nitrogen ring heteroarylradical optionally containing other ring heteroatoms selectedfrom O, N or S; B represents hydrogen, carboxyl, loweralkoxycarbonyl, lower alkyl optionally substituted byamino, lower alkoxy,lower alkoxycarbonyl or carboxyl, oramino optionally substituted by one or two lower alkylgroups, which compounds possess antihypertensive and anti-thrombotic activity.