REDUCTION OF OXYRADICAL DAMAGE IN BIOMEDICAL APPLICATIONS

摘要

The biliproteins delta-bilirubin and delta-bilipeptide are useful as cytoprotective antioxidants. Delta-bilipeptide as the term is used herein is a truncated form of delta-bilirubin in which an albumin analogue of 10 - 200 amino acid residues replaces the albumin portion of delta-bilirubin. Patient administrable compositions for addition to a patient's blood to minimize oxyradical damage caused by ischemia-reperfusion injury that may result in various surgical procedures, and comprising delta-bilirubin or delta-bilipeptide, are described.