IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, NOVEL INTERMEDIATE PRODUCTS, THEIR APPLICATIONS AS PHARMACEUTICALS AND PHARMACEUTICAL COMPOSITIONS HOLDING SAME

摘要

ABSTRACT OF THE DISCLOSURE: The invention relates to the products of formula (I): (I) wherein: A is residue of a radical as boxyclique-or heterocyclic saturated or unsaturated, R represents alkyl, alkenyl or alkynyl; R1, R2, R3 and R4 are hydrogen; halogen; hydroxyl; cyano; nitro; sulfo; formyl; benzoyl; acyl; acyloxy; carboxy free, salified or esterified; mercapto; alkyl; alkenyl; alkynyl; alkoxy; alkylthio; aryl; arylalkyl; arylalkenyl; - (CH2) m-SO2-X-R14; or in which: either R6 and R7 or R8 and R9, identical or different, represent hydrogen, alkyl, alkenyl, aryl, arylalkyl, and - (CH2) m-SO2-X-R14 where m is 0 to 4, or X R4 is NH2, or X is NH, NH-CO-NH or NH-CO- or single bond and R14 is alkyl, alkenyl or aryl, or R6 and R7 or R8 and R9 together with nitrogen to which they are attached form a carbocyclic or heterocyclic radical, or R8 and R9, identical or different, represent acyl, alkyl or arylsulfonyl; R5 represents alkylene; -Y1 Y-B-Y2 wherein Y1 represents carbocyclic or heterocyclic aryl optionally substituted by R1, R2, R3 and R4, B is either single bond between Y1 and Y2, or -CO-, -NH-CO-, -CO-NH- or -O- (CH2) n- with n represent 0 to 3, Y2 is Y1, if B represents a single bond, hydrogen, cyano, carboxy free, salified or esterified, provided that: when A represents phenyl optionally substituted by halogen, alkyl, alkoxy, acyl, free carboxy or substituted phenyl by 5 fluorine atoms, R5 is -CH2-, and Y is -Y1-B-Y2 wherein Y1 represents unsubstituted phenyl and Y 2 is phenyl substituted ortho free carboxy optionally salified, tetrazolyl, trifluoromethyl-sulphonamide and optionally halogen, alkyl, nitro or methoxy, then B represents -CO-NH- or -O- (CH2) n- where n is 2 or 3, said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomers, and the addition salts with mineral and organic acids or with mineral and organic bases of said products of formula (I). The invention also relates to a method for manufacturing said products, their use for the preparation of medicaments, pharmaceutical compositions containing said products and intermediates for the preparation of said products.