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Novel uses of imidazole derivatives, novel derivatives of imidazole, processes for their preparation, new intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them

机译:咪唑衍生物的新用途,咪唑的新型衍生物,其制备方法,获得的新中间体,其作为药物的用途和含有它们的药物组合物

摘要

PCT No. PCT/FR95/01034 Sec. 371 Date Jan. 31, 1997 Sec. 102(e) Date Jan. 31, 1997 PCT Filed Aug. 1, 1995 PCT Pub. No. WO96/04276 PCT Pub. Date Feb. 15, 1996The invention relates to the new use and the new products of formula (I): IMAGE (I) in which: R1=represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms, R2, R3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R4, -OR4 with R4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, -(CH2)m1-S(O)m2-X-R10 with m1=0 to 4, m2=0 to 2, X represents a single bond or -NH-, -NH-CO-, -NH-CO-NH-, and R10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all the isomer forms and the salts, as medicaments.
机译:PCT号PCT / FR95 / 01034秒371日期1997年1月31日102(e)日期:1997年1月31日; PCT申请日期:1995年8月1日。 WO96 / 04276 PCT公开号日期:1996年2月15日,本发明涉及式(I)的新用途和新产品:<图像>(I)其中:R1 =代表羟基,烷基,烯基,炔基,烷氧基,烷硫基,甲酰基,环烷基, R 2,R 3任选地被杂原子中断,特别是代表卤素,巯基,酰基,羧基,硝基,氰基,氨基,氨基甲酰基,R 4,-OR 4,其中R 4尤其代表氢,烷基,烯基,炔基,酰基,氨基,-( CH2)m1-S(O)m2-X-R10,其中m1 = 0至4,m2 = 0至2,X表示单键或-NH-,-NH-CO-,-NH-CO-NH-, R 10代表烷基,烯基或芳基,Y代表任选取代的芳基,这些产物为所有异构体形式和盐,作为药物。

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