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ASSAY METHOD FOR MUTAGENIC AGENTS AND KIT
ASSAY METHOD FOR MUTAGENIC AGENTS AND KIT
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机译:突变剂和试剂盒的评估方法
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2082955 9118113 PCTABS00008 An assay is disclosed for identifying mutagenic agents which induce large, multilocus deletion events in cultured mammalian cells. The cell lines used are adenine phosphoribosyltransferase heterozygotes derived from CHO cells, which we disclose possess a genomic sequence variation near the above-mentioned gene. We present the nucleotide sequence surrounding this variation, enabling an efficient determination of the proportion of deletion mutants among the mutant colonies induced by the agent to be tested.
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