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USE OF BACULOVIRUS EARLY PROMOTERS FOR EXPRESSION OF FOREIGN GENES IN STABLY TRANSFORMED INSECT CELLS OR RECOMBINANT BACULOVIRUSES
USE OF BACULOVIRUS EARLY PROMOTERS FOR EXPRESSION OF FOREIGN GENES IN STABLY TRANSFORMED INSECT CELLS OR RECOMBINANT BACULOVIRUSES
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机译:使用杆状病毒早期启动子在稳定转化的昆虫细胞或重组杆状病毒中表达外源基因
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2091887 9205265 PCTABS00011 The present invention provides an alternative strategy for baculovirus-mediated foreign gene expression: the promoters from immediate-early or delayed-early baculovirus viral genes were used to obtain the continuous expression of foreign genes in stably-transformed insect cells. The IE1 or the 39K promoters from Autographa californica nuclear polyhedrosis virus can drive the continuous expression of a foreign gene in insect cells with the advantages of more efficient processing, and minimal degradation of recombinant protein products. The recombinant baculoviruses are highly infectious in vivo and resistant to inactivation in nature. Therefore, this virus would be very effective as a delivery system of pesticides.
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