Process for the separation of antifactor VIII:C antibodies, especially for use in the blood plasma purification of a type A haemophiliac

摘要

The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies. Preferably use is made of polystyrene, to which have been fixed groups -SO3Na and -SO2Glu, -SO2Threo, -SO2OHPro or SO2Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.