TREATMENT AND PREVENTION OF ORAL MUCOSITIS WITH GROWTH FACTORS

摘要

The present invention found that growth factors have the potential to rapidly accelerate the healing of inflammation of the oral mucosa produced by chemotherapy and radiation therapy in mammals, especially in the oral cavity. The term "growth factor" here means a biologically active polypeptide that induces cell proliferation which includes both growth factors and their analogues. Included in these factors epidermal growth factor, processors growth factors, nerve growth factor, fibroblast growth factor acidic and basic and the angiogenesis factor, growth factor derived from platelets, growth factors insulin and insulin-like, such as somatomedins, myxomas and growth factors derived from the vaccinia virus. This invention more specifically uses of growth factors which bind to receptors of epidermal growth factors, the growth factors containing six essential cysteine ​​residues, the spacing of which is defined by the structure -Cys- (AA) -Cys (AA) b -Cys (AA) c -Cys-Cys-AA (AA) d -Cys-, where AA is an amino acid residue, a is 7, b is 4 or 5, c is 10 and d is equal to 8. the present invention relates still more specifically to the use of alpha transformer growth factor (TGF-alpha) for the prevention and treatment of inflammation of the oral mucosa.