SLOWLY DISSOCIATING (TIGHT BINDING) DOPAMINE, SEROTONIN OR NOREPINEPHRINE REUPTAKE INHIBITORS AS COCAINE, AMPHETAMINE AND PHENCYCLIDINE ANTAGONISTS

摘要

Methods are disclosed for treating cocaine addiction, acute effects of cocaine, and cocaine craving in mammals using a cocaine antagonist of general formula (I). The methods of treatment can counteract cocaine intoxication and prevent relapse into drug use during and after treatment. Preferably, (1-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-4-[3-phenylpropyl]-piperizine is administered in the range of 0.1 mg to 100 mg per kg body weight per day.