5-HT 3? ANTAGONISTS FOR TREATMENT OF NAUSEA, BRADYCARDIA OF HYPOTENSION ASSOCIATED WITH MYOCARDIAL INSTABILITY

摘要

method of treatment and or prophylaxis of nausea and bradycardia and / or hypotension associated myocardial instability in mammals, for example humans. This method provides for administering to mammals in need of such treatment and / or prophylaxis an effective amount of this and / or prophylactic treatment of an antagonist of the 5-HT3 receptor, for example a compound of formula (I): XAR, or a salt thereof -ci pharmaceutically acceptable, wherein X is phenyl or monocyclic heteroaryl group with 5 or 6 elements. In one case as in the other, each group is fused to a carbocyclic or saturated heterocyclic ring is 5-7 membered unsaturated; A is a connecting portion; and R is a saturated azabicyclic part or a part imidazolyl.