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PROCESS FOR PREPARATION OF 7-(3-ARYL-1-PIPERAZINYL)-AND 7-(3CYCLOHEXYL-1-PIPERAZINYL)-3-QUINOLONE CARBOXYLIC ACID
PROCESS FOR PREPARATION OF 7-(3-ARYL-1-PIPERAZINYL)-AND 7-(3CYCLOHEXYL-1-PIPERAZINYL)-3-QUINOLONE CARBOXYLIC ACID
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机译:制备7-(3-ARYL-1-哌嗪基)-和7-(3-环己基-1-哌嗪基)-3-喹诺酮羧酸的方法
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摘要
Novel 1-cyclopropyl-4-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid antibacterials of the formula IMAGE in which R1 is hydrogen, alkyl with 1 to 4 carbon atoms and optionally substituted by hydroxyl, methoxy, amino, dimethylamino, halogen, cyano or alkoxycarbonyl having 1 or 2 carbon atoms in the alkyl moiety, or is oxoalkyl having up to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, R2 is phenyl or cyclohexyl optionally substituted up to three times by halogen, methyl, phenyl, cyano, hydroxyl, methoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro, or is methylenedioxyphenyl, methylenedioxycyclohexyl, furyl, tetrahydrofuryl or thienyl, and X1 is hydrogen or fluorine, or pharmaceutically ultizable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.
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