STRAIN OF HYBRID CULTURED MAMMALIAN MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODY TO GLUTAMATE RECEPTORS OF HUMAN BRAIN

摘要

the invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 to u0433u0438u0431u0440u0438u0434u043eu043cu043du043eu0439 technology and can be used u0434u043bu00a0 u043eu0431u043du0430u0440u0443u0436u0435u043du0438u00a0 u0433u043bu0443u0442u0430u043cu0430u0442u043du044bu0445 receptors to the brain. purpose to obtain u0438u0437u043eu0431u0440u0435u0442u0435u043du0438u00a0 u00a0u0432u043bu00a0u0435u0442u0441u00a0 u0433u0438u0431u0440u0438u0434u043eu043cu043du043eu0433u043e strain u043fu0440u043eu0434u0443u0446u0438u0440u0443u044eu0449u0435u0433u043e u043cu043eu043du043eu043au043bu043eu043du0430u043bu044cu043du043eu0435 antibody (u043cu043eu043du0430u0442) to u0433u043bu0443u0442u0430u043cu0430u0442u043du044bu043c u0440u0435u0446u0435u043fu0442u043eu0440u0430u043c human brain. the strain has been obtained on the basis of immune spleen cells of mice and cell lines BALB / c mice u043cu0438u0435u043bu043eu043cu043du043eu0439 line x 63 ad 653.u043cu043eu043du0430u0442 belongs to the u0441u0443u0431u043au043bu0430u0441u0441u0443 1d 61. the strain is deposited with the no. u0432u0441u043au043a (p) 363). cells of strain with the standard u0443u0441u043bu043eu0432u0438u00a0u0445 on medium with 20% serum, but also in the form of u0430u0441u0446u0438u0442u043du043eu0439 u0441u0438u043du0433u0435u043du043du044bu0445 tumors in mice.study u0432u0437u0430u0438u043cu043eu0434u0435u0439u0441u0442u0432u0438u00a0 u043cu043eu043du0430u0442 with u043du0435u0439u0440u043eu0440u0435u0446u0435u043fu0442u043eu0440u0430u043cu0438 u0433u043bu0443u0442u0430u043cu0430u0442u0430 immune enzyme analysis method u0432u044bu00a0u0432u0438u043bu043e high specificity, and the possibility of u043fu0440u0438u043cu0435u043du0435u043du0438u00a0 antibodies u0434u043bu00a0 u0432u044bu00a0u0432u043bu0435u043du0438u00a0 u0438u043cu043cu043eu0431u0438u043bu0438u0437u043eu0432u0430u043du043du044bu0445 u0433u043bu0443u0442u0430u043cu0430u0442u043du044bu0445 receptors by immune enzyme method.u0441u0432u00a0u0437u044bu0432u0430u043du0438u0435 u043cu043eu043du0430u0442, u043fu0440u043eu0434u0443u0446u0438u0440u0443u0435u043cu043eu0433u043e strain a HGR - 7C5, u0433u043bu0443u0442u0430u043cu0430u0442u043du044bu043cu0438 re u0446u0435u043fu0442u043eu0440u0430u043cu0438 u0441u0440u0435u0437u0430u0445 drugs in postmortem cerebral cortex rights showed that it was paul u0443u0447u0435u043du043e and suitable u0434u043bu00a0 comparative analysis u0440u0430u0441u043fu0440u0435u0434u0435u043bu0435u043du0438u00a0 u043du0435u0439u0440u043eu0440u0435u0446u0435u043fu0442u043eu0440u043eu0432 u0433u043bu0443u0442u0430u043cu0430u0442u0430 in normal and in the pathology of the central nervous system. and