STRAIN OF HYDRIDE CULTURED MAMMALIAN CELLS MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODY TO BRAIN MYELIN GLYCOPROTEINE, INHIBITING ACTIVITY OF NATURAL HUMAN KILLERS

摘要

the invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 to u0433u0438u0431u0440u0438u0434u043eu043cu043du043eu0439 technology. strain (sh) hybrid cells obtained with cells of mouse u0441u043bu0438u00a0u043du0438u0438 mia - heard the lieutenant sp 2 / 0 cells from spleen of mouse Balb / c, u0438u043cu043cu0443u043du0438u0437u0438u0440u043eu0432u0430u043du043du043eu0439 u0433u043bu0438u043au043eu043f - u0440u043eu0442u0435u0438u0434u043eu043c brain u0441u0432u00a0u0437u0430u043du043d ies with u043cu0438u0435u043bu0438u043du043eu043c. hybrid cells produce immunoglobulin class m. the vaccine cells shh shin gene to mice caused them education u0430u0441u0446u0438u0442u043du043eu0439 tumors.in u0430u0441u0446u0438u0442u0438u0447u0435u0441u043au043eu0439 liquid mouse u0441u043eu0434u0435u0440u0436u0430u0442u0441u00a0 specific antibodies. titer u0440u0430u0437u0432u0435u0434u0435u043du0438u00a0 u0430u0441u0446u0438u0442u0438u0447u0435u0441u043au043eu0439 fluid in u0438u043cu043cu0443u043du0440u0444u0435u0440u043cu0451u043du0442u043du043eu043c analysis 10. the ability to market the antibodies stably u043fu0440u043eu0442u00a0u0436u0435u043du0438u0438 u0441u043eu0445u0440u0430u043du00a0u0435u0442u0441u00a0 at least 16 passages. u043cu043eu043du043eu043au043bu043eu043du0430u043bu043au043du044bu0435 antibodies, u043fu0440u043eu0434u0443u0446u0438u0440u0443u0435u043cu044bu0435 sh, capable of u043fu043eu0434u0430u0432u043bu00a0u0442u044c 40% natural u043au0438u043bu043bu0435u0440u043du0443u044e activity u043cu043eu043du043eu043du0443u043au043bu0435u0430u0440u043eu0432 peripheral human blood.the strain is deposited with the no. u0432u0441u043au043a (p) 453u0434.