the invention u043au0430u0441u0430u0435u0442u0441u00a0 u043fu043eu043bu0438u0446u0438u043au043bu0438 of substances, in particular u043fu043eu043bu0443u0447u0435u043du0438u00a0 ethyl p - of (e) - 2 - (6,7,8,9 - u0442u0435u0442u0440u0430u0433u0438u0434u0440u043e7,7 - dimethyl - 5u043d - u0431u0435u043du0437u043eu0446u0438u043au043bu043eu0433u0435u043fu0442u0435u043d - 2 - yl) - u043fu0440u043eu043fu0435u043du0438u043b - benzoate of implement which can be u0434u043bu00a0 local and systemic therapy of acne, psoriasis and other dermatoses, u0441u043eu043fu0440u043eu0432u043eu0436u0434u0430u044eu0449u0438u0445u0441u00a0 reinforced or pathological u043eu0440u043eu0433u043eu0432u0435u043du0438u0435u043c,and in the inflammatory and u0430u043bu043bu0435u0440u0433u0438 - / of dermatological u043fu043eu0440u0430u0436u0435u043du0438u00a0u0445 goal is the creation of a new more active substances of this class. synthesis of lead reaction u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 sn sn st. sn - u0441u043du00b1u0441 - (0) and (cis), c (sn%), (u0441u043d2) mr. with sn sa sn sn, where (u0441u043d3) u0440u00ae. (CgH,.); "| or a balance or if (oh) - u0441u043d3, - u0441u043d2u0440 (0) (Alk) 2, with Alk - the lower the keel, the anion of chlorine, bromine, iodine, HS04 and u0442u043eu0437u0438u043bu043eu043au0441u0438u0433u0440u0443u043fu043fu0430. a new substance active doses of 0.1 - 50 mg / kg, the therapeutic index (u0440u0435u0433u0440u0435u0441u0441u0438u00a0 u043fu0430u043fu0438u043bu043eu043c reaches above a diameter of 78 against 48%) of table 1. (l, c
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