use of a amp; amp; gamma; - globulins with fc fragment in the treatment of primary glomerulonephritis

摘要

PURPOSE:A remedy for systemic lupus erythematosus or primary glomerulonephritis that contains a gamma globulin having the Fc part. CONSTITUTION:A gamma globulin havin the Fc part, which is obtained by subjecting gamma globulin to chemical or enzymatic treatment causing no destruction of the Fc part, thus being injected for plasmin treatment, is used as an active ingredient to given a remedy for systemic lupus erythematosus or primary glomerulonephritis. It is given intravenously, the dose is 20-100mg/kg/day as gamma globulin and continued for one to several weeks. It seems that, when the globulin reaches the lesion site, excessive amounts of the Fc part bind with the deposite to cleave the bonds between antigen-antibody, resulting in dissolution of the deposit.