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Method for removing pertussis endotoxin, a pertussis toxoid and its production
Method for removing pertussis endotoxin, a pertussis toxoid and its production
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机译:百日咳内毒素,百日咳类毒素的去除方法及其生产
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摘要
The present invention provides a clear and efficient pertussis endotoxin-removing method characterized in that a fluid containing the antiinfective fraction and endotoxin of strains of phase I Bordetella pertussis is supplied with calcium ion in the presence of excess phosphate ion prior to zonal centrifugation and also a pertussis toxoid whose endotoxin content per 10 g of proteinic nitrogen is not more than 0.5 ng and its production method.
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