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Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alfa-cyclodextrin and related intermediate compound
Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alfa-cyclodextrin and related intermediate compound
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机译:通过与α-环糊精和相关中间体化合物络合从起始脂质混合物中分离和纯化单唾液酸神经节苷脂的方法
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摘要
By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GM1) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GM1 with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa- cyclodextrin.
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