NOVEL CEPHAROSPOLIN DERIVATIVE AND ANTIMICROBIAL AGENT

摘要

NEW MATERIAL:A compound expressed by formula I (R represents H, 1-4C alkyl or 2-4C carboxyalkyl). EXAMPLE:7beta-[(Z)-2-( 2-Amino-4-thiazolyl )-2-methoxyiminoacetamide]-3-[2,3-dihy dro-5(1H)-indolizinium-5-yl]thiomethyl-ceph-3-em-4-carboxylic acid. USE:An antimicrobial agent stable to beta-lactamases. PREPARATION:For example, a compound expressed by formula III (R1 represents H or amino-protecting group; R2 represents H or carboxyl-protecting group; X represents acetoxyl or halogen atom) is reacted with 2,3-dihydro-5(1H)- indolizinethione expressed by formula II in a polar solvent such as acetonitrile, etc., preferably under around neutral condition, as necessary, in the presence of an alkali metal halide, normally at room temperature -about 70 deg.C.