METHOD FOR ENHANCING ENANTIO-SELECTIVITY OF CANDIDA LIPASE IN ESTERIFICATION OF CHIRAL ALCOHOL, AND IMMOBILIZED CANDIDA LIPASE

摘要

Lipase from a microorganism of the genus Candida, which is covalently bonded to epsilon-amino groups of lysine by opened epoxide groups of an epoxide-activated macroscopic support by N-alkylation and thus immobilised, a process for its preparation, its use in a process for the enantioselective esterification of enantiomer mixtures of an alcohol, which contains at least one centre of asymmetry in the molecule, with the aid of an enol ester, and a process for the enantioselective transesterification of an enantiomer mixture of an alcohol, which contains at least one centre of asymmetry in the molecule, with the aid of the immobilised lipase in the presence of an enol ester.