PHARMACEUTICAL CONTAINING BUFALIN AND BUFADIENOLIDE AS EFFECTIVE COMPONENTS

摘要

PURPOSE: To obtain new compds. useful in the treatment of tumors such as leukemia as antitumorigenic agents because they have strong induced differentiation actions to various tumorous cells. ;CONSTITUTION: The new compds. are bufalin, cinobufagin and their analogous compds. of formula I-III (where R¹ is H or OH and R² is H, OH or acetyl). They are obtd. by extraction by a known method from senso useful as domestic drug obtd. by gathering and drying excreta from the position gland of tuna bufo or its close relative.;COPYRIGHT: (C)1993,JPO