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GLYCOPROTEINS MODIFIED BY OXIDATION AND FORMATION OF SCHIFF BASES, INHIBITING RIBOSOMES, PROCESS FOR OBTAINING THE SAME, AND IMMUNOTOXINES CONTAINING SUCH GLYCOPROTEIN
GLYCOPROTEINS MODIFIED BY OXIDATION AND FORMATION OF SCHIFF BASES, INHIBITING RIBOSOMES, PROCESS FOR OBTAINING THE SAME, AND IMMUNOTOXINES CONTAINING SUCH GLYCOPROTEIN
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机译:通过氧化和形成席夫夫碱,抑制核糖体,获得相同的过程以及含有这种糖蛋白的免疫毒素修饰的糖蛋白
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摘要
Modified glycoproteins inhibiting ribosomes with a view to endowing them with a long period of activity in vivo, by oxidation of the oside units by reaction of periodate ions and simultaneous blocking of the oxidation product by forming a Schiff base with a suitable primary amine. These glycoproteins are suitable for obtaining immunotoxins with long in-vivo activity by coupling an antibody or an antibody fragment with such a glycoprotein.
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