首页>
外国专利>
SULFOADENOSYL-L-METHIONINSALT AND METHOD FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING ONE OR MORE such salts
SULFOADENOSYL-L-METHIONINSALT AND METHOD FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING ONE OR MORE such salts
展开▼
机译:磺基十二烷基L-甲基蛋氨酸盐及其制备方法,以及包含一种或多种此类盐的药物组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles. Said salts correspond to the general formula: SAMe.n(CH2)m(SO3H)2(I) where n can vary from 1 to 2 and m can vary from 3 to 12. The process for producing said salts consists of the following stages: (a) enriching the starting yeast with SAMe; (b) lysing the cells and recovering a solution rich is SAMe (cell lysate); (c) prepurifying the cell lysate by ultrafiltration; (d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; (e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; (f) concentrating the eluate of the latter column by reverse osmosis; (g) drying the concentrated solution.
展开▼