MICROPARTICLES COMPRISING A BIODEGRADABLE POLYMER CONTROLLING THE RELEASE OF AN ANTIMALARIAL DRUG, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

摘要

The invention relates to microparticles containing an antimalarial drug such as primaquine, one of its amino acid derivatives or their conjugates with a hepatotropic carrier or their pharmaceutically acceptable salts, and a biocompatible and biodegradable polymer controlling the kinetics of release of the drug, such as DL-polylactide. …??The invention also relates to pharmaceutical compositions containing the microcapsules according to the invention. …??Lastly, the invention relates to processes for preparing microparticles as defined above, wherein:… - the polymer is dissolved in a volatile solvent,… - the drug and, where appropriate, a substance regulating the size of the microparticles are added to this solution,… - following evaporation, the microparticles are recovered by centrifugation and filtration.