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New derivatives of dihydrobenzofuran - and chroman - carboxamides, 1995 of preparation and their use as neuroleptics

机译:二氢苯并呋喃和苯并二氢呋喃甲酰胺的新衍生物,1995年制备及其作为抗精神病药的用途

摘要

The invention relates to new dihydrobenzofuran- and chroman-carboxamide derivatives of the general formula: IMAGE (I) in which R and R' are each hydrogen or methyl; n is 1 or 2; m is 1 or 2; Z is either IMAGE (a) wherein R1 and R2 are lower alkyl, or IMAGE (b) wherein R3 is alkyl, alkenyl, cycloalkyl-alkyl, cycloalkenyl-alkyl, X is H, NH2, methoxy, or methyl and Y is H, Cl, cycloalkylmethylsulfonyl, alkylsulfamoyl or alkylsulfonyl and to their pharmacologically acceptable acid addition salts and their optical isomers, to the processes for the preparation thereof and to the use thereof as medicaments, especially as neuroleptics.
机译:本发明涉及通式为的新的二氢苯并呋喃和苯并二氢呋喃酰胺衍生物。 n为1或2; m为1或2; Z为(a),其中R1和R2为低级烷基,或(b),其中R3为烷基,烯基,环烷基-烷基,环烯基-烷基,X为H,NH2,甲氧基或甲基,并且Y是H,Cl,环烷基甲基磺酰基,烷基氨磺酰基或烷基磺酰基,以及它们的药理学上可接受的酸加成盐和它们的旋光异构体,及其制备方法及其作为药物的用途,尤其是作为精神抑制药。

著录项

  • 公开/公告号GR3003653T3

    专利类型

  • 公开/公告日1993-03-16

    原文格式PDF

  • 申请/专利权人

    申请/专利号GR19920400082T

  • 发明设计人

    申请日1992-01-27

  • 分类号C07D307/79;A61K;A61K31/33;A61K31/335;A61K31/34;A61K31/343;A61K31/35;A61K31/352;A61K31/395;A61K31/40;A61K31/4025;A61K33/34;A61K33/40;A61M;A61P25;A61P25/08;C07C;C07D;C07D207;C07D207/09;C07D307;C07D307/77;C07D307/78;C07D307/82;C07D307/84;C07D309;C07D311;C07D311/02;C07D311/04;C07D311/20;C07D311/58;C07D311/74;C07D405;C07D405/12;C07D407;C07D407/12;

  • 国家 GR

  • 入库时间 2022-08-22 05:11:47

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