TETRAHYDROIMIDAZO(4,5,1-JK)(1,4)BENZODIAZEPINONE DERIVATIVES AND ANTIVIRAL COMPOSITIONS

摘要

Novel antiviral tetrahydroimidazo[1,4]benzodiazepin-2-ones of formula CHEM a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein R1 is hydrogen, C1-8alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkylcarbonyl, C3-6cycloalkyl, or substituted C1-6alkyl; R2 is hydrogen, C1-6alkyl or C3-6alkenyl R3 is hydrogen or C1-6alkyl; R4 is hydrogen; substituted C1-6alkyl; C1-6alkylcarbonyl; C3-6alkenyl; C3-6cycloalkyl; C5-6cycloalkenyl; R5 is hydrogen, C1-6alkyl or halo; and aryl is optionally substituted phenyl; pharmaceutical compositions containing these compounds as active ingredient; processes for preparing said compounds and compositions.