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PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS CONTAINING IMIDAZOL DERIVATIVES OF ANTINOCICEPTIVE ACTIVITY
PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS CONTAINING IMIDAZOL DERIVATIVES OF ANTINOCICEPTIVE ACTIVITY
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机译:包含抗咪唑活性的咪唑衍生物的药物组合物的制备方法
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摘要
This invention relates to local epidural or intraspinal use of compounds of the formula: CHEM where X is H or CH3 and R1 and R2, which can be the same or different, are each H or CH3 and their stereoisomers and their non-toxic, pharmaceutically acceptable salts. Especially useful are the compounds known under the generic names medetomidine ((+/-)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole), dexmedetomidine (+)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole and detomidine 4-(2,3-dimethylbenzyl)-1H-imidazole.
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