Sulfonildecahidro - 8h - 2.1 - isoquino g 1,6 naftiridinas, Optical isomers of the same and related compounds

摘要

Compounds of the formula (I): CHEM in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, -(CH2)mOR1 or -NR1R2, wherein m is an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl, or the group -NR1R2 forms a heterocycle of the formula: CHEM wherein A is -CH2-, -NR1- or oxygen, wherein R1 has the above meaning and the wavy lines indicate that the hydrogen atom attached thereto is in either the alpha - or beta -position; or a pharmaceutically acceptable salt thereof, are useful as selective alpha 2-blockers.