Controlled release Preparation containing a Salt Metoprolol and Method for its production

摘要

The present Invention refers to preparation of controlled release of Metoprolol releases the active substance continuously over a period of at least 15 hours,A virtually independent of the PH of the Gastrointestinal TractCharacterized by including a Plurality of Granules comprising at least 95 per cent by weight / weight of a soluble Salt of Metoprolol as the main component.The Salt has a Lower solubility of 600 mg / ml in water at 25 deg C and that each granule is coated with a Polymer Membrane containing Cellulose derivatives without protolizables groups and poR which is the main part of the active substance is released in an amount of 3 - 7 percent weight / weight / hour.