THYMOPOIETIN OR THYSPLENIN TETRAPEPTIDE ANALOGUES WITH T-CELL SUPPRESSOR ACTIVITY AND PHARMACEUTICAL COMPOSITIONS

摘要

Peptides having the biological activity of the molecule human thymopentin, namely the ability to increase cGMP activity in human T-cell line CEM, have the formula R-Arg-X-Asp-Y-NR1R2 wherein R is H, lower alkyl, acetyl, formyl lower alkanoyl; X is Pro, dehydro-Pro, hydroxyl-Pro, D-Lys, Aib or Lys; Y is Gly or a D or L form of an amino acid selected from Val, Ala, Ile, Leu, Asp, Glu, Gln or Lys; R1 is H and R2 is lower alkyl or alkenyl having 1 to 10 carbon atoms, cyclic alkyl or alkenyl having 4 to 8 carbon atoms, aryl or NHR3, where R3 is a lower alkyl having 1 to 10 carbon atoms, cyclic alkyl or alkenyl having 4 to 8 carbon atoms, or aryl; or R1 and R2 together comprise a methylene chain of 4 to 7 carbon atoms. These peptides can be used in pharmaceutical compositions for regulating a deficiency or excess of T-cell function in human subjects.