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AQUEOUS COMPOSITIONS WHICH GEL REVERSIBLY AS TEMPERATURE AND PH CHANGE (CONTAINING TWO SUITABLE POLYMERS); USE AS A CARRIER FOR MEDICAMENTS
AQUEOUS COMPOSITIONS WHICH GEL REVERSIBLY AS TEMPERATURE AND PH CHANGE (CONTAINING TWO SUITABLE POLYMERS); USE AS A CARRIER FOR MEDICAMENTS
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机译:凝胶随着温度和PH值的变化而反向变化的水性组合物(包含两种合适的聚合物);用作药物载体
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摘要
Reversibly gelling aqueous compositions are disclosed which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer and at least one temperature-sensitive reversibly gelling polymer. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.
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