process for the preparation of immunogeni exogenous antigen can generate not only the immune response of lymphocytes thelper.but also effective response of cytotoxic t lymphocytes; and immunogeni so obtainable.

摘要

The process for the preparation of immunogens according to the invention is characterized by synthetically bonding at least one exogenous antigen to the exogenous form of hepatitis B virus envelope antigen, such immunogens being capable of eliciting, against the synthetically bonded antigen, not only an immune response of T helper lymphocytes (class II-restricted) but also an effective response of cytotoxic T lymphocytes (class I-restricted). The synthetically bonded antigens can be selected for example from the group comprising proteins of AIDS virus, recombinant proteins of AIDS virus, synthetic peptides of AIDS virus, proteins of malaria plasmodium and proteins of toxoplasma. The invention extends also to immunogens per se, characterized by the fact of being obtainable with the above process.