PROCEDURE FOR THE SIMULTANEOUS DRYING AND GRANULATING OF EXTRACTS OF UNLEASHED CALF BLOOD, GRANULATING OBTAINED ACCORDING TO THIS PROCEDURE AND ITS USE FOR THE MANUFACTURE OF PHARMACEUTICAL PREPARATIONS.

摘要

THE INVENTION IS RELATED TO A FLUIDIZATION PROCEDURE FOR THE PREPARATION OF A DRY SUBSTANCE OF AQUEOUS SOLUTIONS OF DEPROTEINATED BLOOD EXTRACTS FROM CALFSKINS, AND TO THE SIMULTANEOUS PRODUCTION OF A GRANULATE THAT CAN BE COMPRESSED IN DRUGS. WITH REGARD TO ITS TOTAL WEIGHT IN A DRY STATE, THIS GRANULATE CONTAINS AT LEAST 50% OF THE EXTRACTED SUBSTANCES PLUS A BINDER AND FILLING SUBSTANCES AS WELL AS COMPATIBLE CARRIER SUBSTANCES. GRANULATING IS PREPARED THROUGH THE APPLICATION BY SPRAYING OF AN AQUEOUS SOLUTION OF THE EXTRACTS AND OF THE BINDER ON THE CARRIER AND FILLING SUBSTANCES, GRANULATING THE MIXED LOAD WITH A WATER CONTENT DETERMINED IN THE FLUIDIZATION PROCEDURE. AFTER DRYING, A GRANULATE WILL BE OBTAINED, READY TO COMPRESS, WHICH CAN BE USED FOR THE PRODUCTION OF MEDICINES IN A SOLID FORM THAT OFFERS GREAT STABILITY AND CONSTANT QUALITY.