首页> 外国专利> Process for the simultaneous drying and granulation of an extract from deproteinated calf's blood, granulate obtained by this process and its use in the preparation of pharmaceutical compositions

Process for the simultaneous drying and granulation of an extract from deproteinated calf's blood, granulate obtained by this process and its use in the preparation of pharmaceutical compositions

机译:同时干燥和制粒去蛋白牛血提取物的方法,该方法制得的颗粒及其在制备药物组合物中的用途

摘要

The invention relates to a fluidized-bed method for simultaneously obtaining the dry matter from aqueous solutions of extract substances from deproteinized calves blood and producing granules which can be compressed to give solid medicament forms and contain at least 50% by weight of extract substances, relative to the total dry weight of the granules, a binder and pharmaceutically acceptable fillers and carriers, by spraying an aqueous solution of the extract substances and of the binder on to the fillers and carriers and granulating the mixed material at a defined water content in the fluidized bed. After drying, granules ready for compression are obtained, and they are used for producing solid medicament forms of high stability and constant quality.
机译:本发明涉及一种流化床方法,该方法同时从脱蛋白的牛血中提取物质的水溶液中获得干物质,并生产可被压制成固体药物形式并含有至少50%(重量)提取物质的颗粒。通过将提取物和粘合剂的水溶液喷雾到填充剂和载体上,并在流态化器中以规定的水含量造粒混合材料,将颗粒,粘合剂和药学上可接受的填充剂和载体的总干重降低至颗粒的总干重床。干燥后,获得准备压制的颗粒,它们被用于生产高稳定性和恒定质量的固体药物形式。

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