OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING A MODERATELY WATER-SOLUBLE METOPROLOL SALT HAVING IMPROVED CORE COMPOSITION AND USE THEREOF

摘要

4-16168/=/CGC 1232OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING AMODERATELY WATER-SOLUBLE METOPROLOL SALT HAVING IMPROVED CORECOMPOSITION AND USE THEREOFABSTRACT OF THE DISCLOSUREAn osmotic dispensing oral delivery system containing a moderatelywater-soluble metoprolol salt for total delivery of between about 50and about 500 mg of metoprolol wherein from about 60 up to about 90percent of said metoprolol is released in the gastro-intestinaltract at a substantially continuous rate of about 5 to about 12percent by weight per hour comprising:a) a semipermeable shaped wall membrane substantially imper-meable to said salt and permeable to gastrointestinalfluid,b) a core compartment within and defined by said wall, saidcore containing a solid osmotically active compositioncomprising: about 7.5 to about 15 percent by weightpoly-N-vinylpyrrolidone; up to about 5 percent by weightof a tabletting lubricant; and about 92.5 to about 80percent by weight of said metoprolol salt, based on thecore composition weight andc) at least one passageway in the wall, for dispensing themetoprolol salt, in communication with said core compart-ment and the external environment,and a method of use thereof in conditions responsive to beta1-adrenoreceptor blocking agents.