L-PHENYLALANYL-TRNA SYNTHETASE MUTANTS, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR THE IN VIVO INCORPORATION OF NON-PROTEINOGENOUS AMINO ACIDS INTO PEPTIDES OR PROTEINS

摘要

of the disclosure HOE 91/F 392G L-Phenylalanyl-tRNA synthstase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins The invention relates to L-phenylalanyl-tRNA synthetases from microorganisms which, by reason of a modification generated by genetic engineering, have an altered substrate selectivity, and to their preparation and use for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins.