Bifunctional antithrombotic molecules and antithrombotic polypeptides

摘要

A bifunctional molecule is provided that is capable of inhibiting activation of a platelet and/or adhesion of a platelet to a damaged or diseased vascular domain and is capable of inhibiting the binding of thrombins to platelet glycoprotein Ibalpha and the second domain is capable of inhibiting the binding of von Willebrand factor to platelet glycoprotein Ibalpha. Also, a therapeutic composition containing the bifunctional molecule is provided. The process of producing the bifunctional molecule is by culturing a host organism transformed with a biologically functional expression plasmid that contains a DNA sequence encoding the bifunctional molecule under conditions which effect expression of the molecule by the host organism, and recovering the molecule from it.