Sequences for a 90K tumor-associated antigen, immunoregulin-95 (IR-95)

摘要

This invention provides substantially purified tumor-associated 90K antigen, or fragment(s) thereof, especially from: the culture fluid of the human breast cancer cell line, CG-5; the serum of a breast cancer patient; or the ascitic fluid from an ovarian cancer patient. The native antigen, which has a molecular weight of about 95,000 daltons, is present as a high molecular weight complex. The purification and characterization of the antigen is provided as well as uses thereof. The nucleotide sequences which encode the 90K antigen, or fragment(s) thereof, vehicles containing the genetic sequence, hosts transformed therewith, and production of the antigen, or fragments thereof, by the transformed host are also provided.