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AMPHOTERICIN B COMPOSITION WITH ENHANCED ANTIFUNGAL ACTIVITY
AMPHOTERICIN B COMPOSITION WITH ENHANCED ANTIFUNGAL ACTIVITY
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机译:具有增强的抗真菌活性的两性霉素B组合物
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摘要
Fungal infections are treated by administering a combination of: (a) amphotericin B, and (b) a glycerol ether selected from the group consisting of (i) HOCH2CHOHCH2OR, (ii) HOCH2CH(OR1)CH2OH, and (iii) combinations thereof, wherein R and R1 are independently selected from the group consisting of C8-C18 alkyl and C8-C18 alkenyl. The glycerol ether acts synergistically to reduce the minimum inhibitory concentration of amphotericin B. The combination is particularly effective against Cryptococcus and Candida species.
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