METHOD OF USING M1-SELECTIVE ANTIMUSCARINIC PYRIDOBENZODIAZEPINONES IN AXIAL MYOPIA THERAPY

摘要

Pyridobenzodiazepinones of formula (I) wherein R is piperidine substituted by C1-5 alkyl, are ocularly administered to animals to prevent abonormal increases in eye axial length and thereby arrest the progression of axial myopia. The compounds are pharmacologically characterized in that they selectively antagonize the binding of acetylcholine to M1-type muscarine receptors.