Use of M1-selective antimuscarinic pyridobenzodiazepinones for the treatment and prevention of axial myopia

摘要

Pyridobenzodiazepinones of the formula: wherein R is piperidine substituted by C₁₋₅ alkyl, are ocularly administered to animals to prevent abnormal increases in eye axial length and thereby arrest the progression of axial myopia. The compounds are pharmacologically characterized in that they selectively antagonize the binding of acetylcholine to M₁-type muscarine receptors.