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INTERMEDIATES AND A PROCESS FOR SYNTHESIS OF TETRAHYDROPTERIDINE C6-STEREOISOMERS, INCLUDING (6S)-TETRAHYDROFOLATE AND N5-FORMYL-(6S)-TETRHYDROFOLATE
INTERMEDIATES AND A PROCESS FOR SYNTHESIS OF TETRAHYDROPTERIDINE C6-STEREOISOMERS, INCLUDING (6S)-TETRAHYDROFOLATE AND N5-FORMYL-(6S)-TETRHYDROFOLATE
Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as above, wherein R1 and R2 are the same or different and represent hydrogen, methyl, hydroxy, amino, alkyl or dialkylamino, alkoxy, benzyloxy, or benzylthio; R3 represents an alkene, alkyne, cycloalkyl, benzyl, alkyl (substituted with hydroxy, acetoxy, benzyloxy, alkoxy, alkylthio, amino, carboxy, oxo, or phosphate), a protected aldehyde, or (II) wherein n = 1 or 2, R4 is hydrogen, formyl, methyl, or propargyl, and ZZ represents an amino acid or amino acid polymer. Also, a process for tetrahydropteridine N5-formylation for the preparation of, for example, N5-formyl-(6S)-tetrahydrofolic acid.
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机译:中间体和合成6-单取代四氢蝶啶C6-立体异构体,包括(6S)-四氢叶酸的方法。中间体以上述两种对映体形式表示,其中R1和R2相同或不同,代表氢,甲基,羟基,氨基,烷基或二烷基氨基,烷氧基,苄氧基或苄硫基; R3代表烯烃,炔烃,环烷基,苄基,烷基(被羟基,乙酰氧基,苄氧基,烷氧基,烷硫基,氨基,羧基,氧代或磷酸酯取代),被保护的醛或(II),其中n = 1或2, R 4是氢,甲酰基,甲基或炔丙基,并且ZZ表示氨基酸或氨基酸聚合物。同样,四氢蝶啶N5-甲酰化的方法用于制备例如N5-甲酰基-(6S)-四氢叶酸。
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