θ6 METAL COMPLEXES OF 4-ARYL-1,4-DIHYDROPYRIDINES

摘要

The present invention is directed to θ6 metal complexes of the arene group of 4-aryl-1,4-dihydropyridines. The 4-aryl-1,4-dihydropyridines are made according to the Hantzsch pyridine synthesis, and are then reacted with a π acid ligand-metal reagent to attach the metal in an θ6 fashion to the 6π electrons of the arene ring. The 4-aryl-1,4-dihydropyridine metal complexes are designed to provide useful spectroscopic information concerning the conformation of the 4-aryl-1,4-dihydropyridines and how such compounds interact with the calcium channel protein. Moreover, the 4-aryl-1,4-dihydropyridine metal complexes are robust calcium antagonists and compare to or exceed the biological activity of previously known calcium channel antagonists.