METHODS FOR IDENTIFYING AGENTS USEFUL IN TREATING SEPTICEMIA

摘要

This invention relates to a method for identifying compounds useful in the treatment of septicemia comprising: a) forming an infective fibrin clot; b) implanting said clot in the peritoneal cavity of an experimental animal; c) administering to a population of said implanted animals a compound to be tested in the presence of a known anti-infective agent; and d) identifying the compounds which increase the percentage survival in the experimental animal population when compared to a control population. The invention also relates to the treatment of septicemia employing alpha-2-macroglobulin soluble complement receptor-1 and combinations thereof.