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PROTECTIVE FOUR AMINO ACID EPITOPE AGAINST -i(PLASMODIUM VIVAX) MALARIA.
PROTECTIVE FOUR AMINO ACID EPITOPE AGAINST -i(PLASMODIUM VIVAX) MALARIA.
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机译:预防-i(Plasmodium VIVAX)疟疾的四种氨基酸表位。
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摘要
A synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human maleria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.
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