(1R,5S,6S)-2-substituted thio-6 (R)-1-hydroxyethyl -1-methyl-carbapenem - carboxylic acid derivatives

摘要

Novel crystalline carbapenem compounds, (1R,5S,6S)-2-substituted thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylic acid derivatives. These carbapanem compounds are represented by the following formula having a beta-coordinated methyl group introduced into the 1-position and a (methyl-1,2,3-thiadiazolium-4-yl) methylthio group introduced into the 2-position. CHEM They have antibacterial activity, and are used for prevention and treatment of bacterial infections as antibacterial agents. A process for producing these crystalline carbapenem compounds is also provided.