Transgenic rats having at least one human gene in their genome, participating in the regulation of the blood-pressure

摘要

The invention relates to transgenic rats in whose genome at least one human gene whose gene product is involved in the regulation of blood pressure is integrated. The invention further relates to transgenic rats and their progeny which have an elevated blood pressure (90/140 mm Hg) or high blood pressure (95/160 mm Hg). Finally, the invention relates to processes for the production of the transgenic rats according to the invention and their progeny and to the use thereof for pharmacological investigations.